Isolation and Characterization of Two Klebsiella pneumoniae Phages Encoding Divergent Depolymerases.

ABSTRACT: The emergence of multidrug-resistant bacteria is a major global health concern. The search for new therapies has brought bacteriophages into the spotlight, and new phages are being described as possible therapeutic agents. Among the bacteria that are most extensively resistant to current antibiotics is Klebsiella pneumoniae, whose hypervariable extracellular capsule makes treatment particularly difficult. Here, we describe two new K. pneumoniae phages, πVLC5 and πVLC6, isolated from environmental samples. These phages belong to the genus Drulisvirus within the family Podoviridae. Both phages encode a similar tail spike protein with putative depolymerase activity, which is shared among other related phages and probably determines their ability to sp

SUBMITTER: Domingo-Calap P 

PROVIDER: S-EPMC7246685 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature