Chromosome 11q13.5 variant as a risk factor for atopic dermatitis in children.

ABSTRACT:

Introduction

Atopic dermatitis is a chronic inflammatory skin disease with a strong genetic basis. Recent GWASs have identified a single nucleotide polymorphism on chromosome 11q13.5 (rs7927894) as novel susceptibility loci of atopic dermatitis.

Aim

To evaluate the association of this genetic variant with atopic dermatitis and to investigate its possible interaction with filaggrin null mutations in children population.

Material and methods

One hundred eighty-eight children less than 2 years old were screened for the variant of allele of rs7927894 on chromosome 11q13.5 and for the 4 most prevalent filaggrin mutations. The variant of allele of rs7927894 and all filaggrin mutations were genotyped by real-time PCR assays with subsequent melting curve analysis using Simple

SUBMITTER: Debinska A 

PROVIDER: S-EPMC7247065 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature