Cyclophosphamide pulse therapy as treatment for severe interstitial lung diseases.

ABSTRACT:

Introduction

Besides invasive or non-invasive ventilation, treatment of severe forms of interstitial lung diseases (ILD) includes immunosuppressive medication. In case of refractory organ- or life-threatening courses of disease, cyclophosphamide pulse therapy can serve as a rescue treatment option.

Objectives

To investigate therapeutic and prognostic effects of cyclophosphamide for the treatment of severe forms of ILD on intensive care unit (ICU) we performed this analysis.

Methods

Between 2009 and 2017 we identified 14 patients, who were treated on intensive care unit (ICU) with severe forms of ILD. Retrospectively, clinical, radiologic and prognostic data were collected and evaluated.

Results

Our analysis demonstrated a prognostic impact of cyclophosphamide o

SUBMITTER: Schulze AB 

PROVIDER: S-EPMC7247101 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature