Efficient production of myo-inositol in Escherichia coli through metabolic engineering.

ABSTRACT:

Background

The biosynthesis of high value-added compounds using metabolically engineered strains has received wide attention in recent years. Myo-inositol (inositol), an important compound in the pharmaceutics, cosmetics and food industries, is usually produced from phytate via a harsh set of chemical reactions. Recombinant Escherichia coli strains have been constructed by metabolic engineering strategies to produce inositol, but with a low yield. The proper distribution of carbon flux between cell growth and inositol production is a major challenge for constructing an efficient inositol-synthesis pathway in bacteria. Construction of metabolically engineered E. coli strains with high stoichiometric yield of inositol is desirable.

Results

In the present study, we designed an

SUBMITTER: You R 

PROVIDER: S-EPMC7247202 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature