Prognostic impact of Dynamin related protein 1 (Drp1) in epithelial ovarian cancer.

ABSTRACT:

Background

The mitochondrial fission protein, Dynamin related protein 1 (Drp1), and its upstream protein calcium/calmodulin-dependent protein kinase I (CaMKI) play a critical role in chemoresistance in ovarian cancer (OVCA). Thus, we examined the expression of Drp1, CaMKI and their phosphorylated forms and their prognostic impact in epithelial OVCA patients.

Methods

Expression analysis was performed by immunohistochemistry (IHC) of paraffin-embedded tumor samples from 49 patients with epithelial OVCA. Staining intensity and the percentage of positively stained tumor cells were used to calculate an immunoreactive score (IRS) of 0-12. The expression scores calculated were correlated with clinicopathological parameters and patient survival.

Results

High immunoreactivity

SUBMITTER: Tsuyoshi H 

PROVIDER: S-EPMC7247242 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature