A randomized controlled study of immediate versus delayed umbilical cord clamping in infants born by elective caesarean section.

ABSTRACT: BACKGROUND:Delayed umbilical cord clamping is associated with greater haemoglobin concentration and iron storage between 3 and 6?months of life and with less need of blood transfusion and lower incidence of neonatal hypotension compared to early umbilical cord clamping. METHODS:The aim was to test the hypothesis that delayed cord clamping is better than early cord clamping in term infants born by elective caesarean section. Group A was subjected to immediate cord clamping while in the Group B, the umbilical cord was clamped 1?min after birth. Primary aim was revealed the difference in pre-ductal saturation between two groups while secondary aim was investigating the difference in HR, Ht, bilirubin and glycaemia. Pre-ductal SpO2 and HR were recorded at 5 and 10?min after birth, T was analysed 10?min after birth, glycaemia was revealed at 120?min while Ht and bilirubin were collected at 72?h. RESULTS:132 newborns were enrolled in the study and allocated in ratio 1:1 to group A or B. Delayed cord clamping did not improve SpO2, HR and T values compared to immediate cord clamping (p?>?0,05). However, Group B showed greater haematocrit and bilirubin values at 72?h compared to Group A (56,71 ±?6663 vs 51,56 ±?6929; p??0,05). CONCLUSIONS:Group B did not reveal any differences in SpO2, HR, T and glycaemia compared to Group A. Group B showed greater values of haematocrit and bilirubin but without need of phototherapy. TRIAL REGISTRATION:Umbilical Cord Clamping: What Are the Benefits; NCT03878602. Registered 18 March 2019 retrospectively registered.

SUBMITTER: De Bernardo G 

PROVIDER: S-EPMC7247269 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature