TinderMIX: Time-dose integrated modelling of toxicogenomics data.

ABSTRACT:

Background

Omics technologies have been widely applied in toxicology studies to investigate the effects of different substances on exposed biological systems. A classical toxicogenomic study consists in testing the effects of a compound at different dose levels and different time points. The main challenge consists in identifying the gene alteration patterns that are correlated to doses and time points. The majority of existing methods for toxicogenomics data analysis allow the study of the molecular alteration after the exposure (or treatment) at each time point individually. However, this kind of analysis cannot identify dynamic (time-dependent) events of dose responsiveness.

Results

We propose TinderMIX, an approach that simultaneously models the effects of time and dose

SUBMITTER: Serra A 

PROVIDER: S-EPMC7247400 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature