Polysaccharide-Based Injection Matrix for Serial Crystallography.

ABSTRACT: Serial crystallography (SX) provides an opportunity to observe the molecular dynamics of macromolecular structures at room temperature via pump-probe studies. The delivery of crystals embedded in a viscous medium via an injector or syringe is widely performed in synchrotrons or X-ray free-electron laser facilities with low repetition rates. Various viscous media have been developed; however, there are cases in which the delivery material undesirably interacts chemically or biologically with specific protein samples, or changes the stability of the injection stream, depending on the crystallization solution. Therefore, continued discovery and characterization of new delivery media is necessary for expanding future SX applications. Here, the preparation and characterization of new polysaccha

SUBMITTER: Nam KH 

PROVIDER: S-EPMC7247560 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature