Variations in the Wnt/β-Catenin Pathway Key Genes as Predictors of Cervical Cancer Susceptibility.

ABSTRACT:

Background

Cervical cancer is the fourth most common and fatal tumor among women worldwide. The Wnt/β-catenin signaling pathway was etiologically involved in the cervical cancer model. Herein, we aimed to investigate whether germline genetic variations within the Wnt/β-catenin pathway can be genetic risk factors of cervical cancer.

Patients and methods

A total of 305 samples (147 patients, 158 controls) were included. Eight genetic variations located in APC (rs454886), GSK3β (rs3755557), CTNNB1 (rs11564475, rs1798802, rs3864004, rs2293303, and rs4135385), and TCF7L2 (rs7903146) were genotyped via Sanger sequencing. The χ ² test and non-conditional logistic regression were used in the single-locus analysis. Gene-gene interactions and haplotype construction i

SUBMITTER: Wang B 

PROVIDER: S-EPMC7247596 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature