Particulate Air Pollution, Clock Gene Methylation, and Stroke: Effects on Stroke Severity and Disability.

ABSTRACT: Circadian rhythm disturbances have been consistently associated with the development of several diseases, particularly cardiovascular diseases (CVDs). A central clock in the brain maintains the daily rhythm in accordance with the external environment. At the molecular level, the clock is maintained by "clock genes", the regulation of which is mainly due to DNA methylation, a molecular mechanism of gene expression regulation, able to react to and be reprogrammed by environmental exposure such as exposure to particulate matter (PM). In 55 patients with a diagnosis of acute ischemic stroke, we showed that PM2.5 exposure experienced before the event influenced clock genes methylation (i.e., circadian locomotor output cycles protein kaput CLOCK, period 2 PER2, cryprochrome 1 CRY1, Neuronal PAS

SUBMITTER: Cantone L 

PROVIDER: S-EPMC7247663 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature