Proteomic Profiling of Colon Cancer Tissues: Discovery of New Candidate Biomarkers.

ABSTRACT: Colon cancer is an aggressive tumor form with a poor prognosis. This study reports a comparative proteomic analysis performed by using two-dimensional differential in-gel electrophoresis (2D-DIGE) between 26 pooled colon cancer surgical tissues and adjacent non-tumoral tissues, to identify potential target proteins correlated with carcinogenesis. The DAVID functional classification tool revealed that most of the differentially regulated proteins, acting both intracellularly and extracellularly, concur across multiple cancer steps. The identified protein classes include proteins involved in cell proliferation, apoptosis, metabolic pathways, oxidative stress, cell motility, Ras signal transduction, and cytoskeleton. Interestingly, networks and pathways analysis showed that the identified pro

SUBMITTER: Buttacavoli M 

PROVIDER: S-EPMC7247674 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature