Recent advances in the understanding of trimeric autotransporter adhesins.

ABSTRACT: Adhesion is the initial step in the infection process of gram-negative bacteria. It is usually followed by the formation of biofilms that serve as a hub for further spread of the infection. Type V secretion systems engage in this process by binding to components of the extracellular matrix, which is the first step in the infection process. At the same time they provide protection from the immune system by either binding components of the innate immune system or by establishing a physical layer against aggressors. Trimeric autotransporter adhesins (TAAs) are of particular interest in this family of proteins as they possess a unique structural composition which arises from constraints during translocation. The sequence of individual domains can vary dramatically while the overall structure c

SUBMITTER: Kiessling AR 

PROVIDER: S-EPMC7247746 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature