Childhood Trauma Is Nominally Associated With Elevated Cortisol Metabolism in Severe Mental Disorder.

ABSTRACT:

Objective

Individuals exposed to childhood trauma display longstanding modifications of the Hypothalamic-Pituitary-Adrenal (HPA) axis, as well as cognitive impairments. Schizophrenia spectrum disorder (SZ) and bipolar disorders (BD) are characterised by higher prevalence of childhood trauma, abnormal HPA axis, and cognitive dysfunction. Elevated cortisol metabolism was recently demonstrated in both disorders. However, it is yet to be established if childhood adversity is associated with cortisol metabolism in this population, and how this may be associated with cognitive function.

Methods

One-hundred-and-fourteen participants with a DSM-IV SZ or BD diagnosis took part in the study. Diagnoses were evaluated by the Structured Clinical Interview for DSM-IV Axis I disorders (SCI

SUBMITTER: Aas M 

PROVIDER: S-EPMC7247816 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature