Normal Hematopoetic Stem and Progenitor Cells Can Exhibit Metabolic Flexibility Similar to Cancer Cells.

ABSTRACT: It is known that cancer stem cells (CSCs) with the largest proliferative capacity survive the anoxic and/or ischemic conditions present inside tumorous tissue. In this study we test whether normal stem cells can survive under the same conditions due to cancer cell-like metabolic adaptations. We cultivated a CD34⁺ population with a majority of hematopoietic progenitors, and a CD34⁺CD38^lowCD133⁺CD90⁺CD45RA^- population, highly enriched in hematopoietic stem cells (HSCs), under anoxic, anoxic/aglycemic ("ischemia-like"), or physiological conditions (3% O₂). Results showed, despite a reduction in total cell fold expansion proportionate to the decrease in O₂ concentration; CD34⁺ cells, aldehyde deh

SUBMITTER: Vlaski-Lafarge M 

PROVIDER: S-EPMC7247845 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature