Evaluating the Effect of Interleukin-4 in the 3xTg Mouse Model of Alzheimer's Disease.

ABSTRACT: Chronic neuroinflammation has long been hypothesized to be involved in Alzheimer's Disease (AD) progression. Previous research suggests that both anti-inflammatory and inflammatory microglia ameliorate amyloid pathology, but the latter worsen tau pathology. In this study, we sought to determine whether induction of arginase-1 positive microglia with the anti-inflammatory cytokine IL-4 modulates pathology in the 3xTg mouse model of AD. Our findings indicate that a single intracranial IL-4 injection positively modulated performance of 3xTg AD mice in a Novel Object Recognition task, and locally increased the levels of arginase-1 positive myeloid cells when assessed one-week post injection. Furthermore, immunohistochemical analysis revealed decreased tau phosphorylation in IL-4 injected anima

SUBMITTER: Dionisio-Santos DA 

PROVIDER: S-EPMC7247853 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature