Lucina pectinata oxyhemoglobin (II-III) heterodimer pH susceptibility.

ABSTRACT: Lucina pectinata live in high concentrations of hydrogen sulfide (H₂S) and contains one hemoglobin, Hemoglobin I (HbI), transporting H₂S and two hemoglobins, Hemoglobin II (HbII) and Hemoglobin (HbIII), transferring dioxygen to symbionts. HbII and HbIII contain B10 tyrosine (Tyr) and E7 glutamine (Gln) in the heme pocket generating an efficient hydrogen bonding network with the (HbII-HbIII)-O₂ species, leading to very low ligand dissociation rates. The results indicate that the oxy-hemeprotein is susceptible to pH from 4 to 9, at acidic conditions, and as a function of the potassium ferricyanide concentration, 100% of the met-aquo derivative is produced. Without a strong oxidant, pH 5 generates a small concentration of the met-aquo complex. The process is a

SUBMITTER: Marchany-Rivera D 

PROVIDER: S-EPMC7247926 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature