CD4⁺ Resident Memory T Cells Mediate Long-Term Local Skin Immune Memory of Contact Hypersensitivity in BALB/c Mice.

ABSTRACT: In allergic contact dermatitis (ACD) and contact hypersensitivity (CHS), the healed skin shows greater swelling than the naïve skin in the same individual upon re-exposure to the same hapten. This "local skin memory" (LSM) in healed skin was maintained for a prolonged period of time and mediated by skin CD8⁺-resident memory T (T_RM) cells in C57BL/6 mice. However, the number of CD4⁺ T cells is elevated in ACD-healed human skin, and the contribution of CD4⁺ T_RM cells to the formation of LSM currently remains unclear. We herein demonstrated that immediately after CHS subsided, the healed skin in BALB/c mice showed an accumulation of hapten-specific CD4⁺ and CD8⁺ T_RM cells, with a predominance of CD4^+<

SUBMITTER: Murata A 

PROVIDER: S-EPMC7248184 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature