Gut Dysbiosis Thwarts the Efficacy of Vaccine Against Mycobacterium tuberculosis.

ABSTRACT: The generation of enduring protective immunity by vaccines is of utmost importance. Intriguingly, there is considerable variation in the efficacy of vaccines amongst individuals. Various studies have shown that normal flora of gastrointestinal tract plays a vital role in maintaining host homeostasis and immunity. Since gut microbiome is also extremely variable between individuals, we speculate that it might impact individual's response to vaccines. Consequently, we administered broad spectrum antibiotics cocktail to induce gut dysbiosis and monitored its impact on the generation of long-lasting memory T cells and thereby BCG vaccine efficacy. Interestingly, gut dysbiosis significantly decreased the activation of CD4⁺ T cells and CD8⁺ T cells. Further, there was declin

SUBMITTER: Nadeem S 

PROVIDER: S-EPMC7248201 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature