The Migratory Properties and Numbers of T Regulatory Cell Subsets in Circulation Are Differentially Influenced by Season and Are Associated With Vitamin D Status.

ABSTRACT: The control of peripheral immune responses by FOXP3⁺ T regulatory (Treg) cells is essential for immune tolerance. However, at any given time, Treg frequencies in whole blood can vary more than fivefold between individuals. An understanding of factors that influence Treg numbers and migration within and between individuals would be a powerful tool for cellular therapies that utilize the immunomodulatory properties of Tregs to control pathology associated with inflammation. We sought to understand how season could influence Treg numbers and phenotype by monitoring the proportion of natural thymus-derived Tregs (nTregs) defined as (CD3⁺CD4⁺CD25⁺FOXP3⁺CD127^-/low ) cells as a proportion of CD4⁺ T cells and compa

SUBMITTER: Lamikanra AA 

PROVIDER: S-EPMC7248210 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature