Pressure and Flow Relations in the Systemic Arterial Tree Throughout Development From Newborn to Adult.

ABSTRACT: Objective: Distributed models of the arterial tree allow studying the effect of physiological and pathophysiological changes in the vasculature on hemodynamics. For the adult, several models exist; however, a model encompassing the full age range from newborn to adult was until now lacking. Our goal is to describe a complete distributed hemodynamic model for normal development from newborn to adult. Methods: The arterial system was modeled by 121 segments characterized by length, radius, wall thickness, wall stiffness, and wall viscosity. The final segments ended in three-element Windkessels. All parameters were adapted based on body height and weight as a function of age as described in the literature. Results: Pressures and flows are calculated as a function of age a

SUBMITTER: Westerhof BE 

PROVIDER: S-EPMC7248228 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature