Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines.

ABSTRACT: Adenoviral vectors are a safe and potently immunogenic vaccine delivery platform. Non-replicating Ad vectors possess several attributes which make them attractive vaccines for infectious disease, including their capacity for high titer growth, ease of manipulation, safety, and immunogenicity in clinical studies, as well as their compatibility with clinical manufacturing and thermo-stabilization procedures. In general, Ad vectors are immunogenic vaccines, which elicit robust transgene antigen-specific cellular (namely CD8⁺ T cells) and/or humoral immune responses. A large number of adenoviruses isolated from humans and non-human primates, which have low seroprevalence in humans, have been vectorized and tested as vaccines in animal models and humans. However, a distinct hierarchy

SUBMITTER: Coughlan L 

PROVIDER: S-EPMC7248264 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature