Genome-Wide Gene-Based Multi-Trait Analysis.

ABSTRACT: Genome-wide association studies focusing on a single phenotype have been broadly conducted to identify genetic variants associated with a complex disease. The commonly applied single variant analysis is limited by failing to consider the complex interactions between variants, which motivated the development of association analyses focusing on genes or gene sets. Moreover, when multiple correlated phenotypes are available, methods based on a multi-trait analysis can improve the association power. However, most currently available multi-trait analyses are single variant-based analyses; thus have limited power when disease variants function as a group in a gene or a gene set. In this work, we propose a genome-wide gene-based multi-trait analysis method by considering genes as testing units. F

SUBMITTER: Deng Y 

PROVIDER: S-EPMC7248273 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature