Development of a Multi-Pulse Conductivity Model for Liver Tissue Treated With Pulsed Electric Fields.

ABSTRACT: Pulsed electric field treatment modalities typically utilize multiple pulses to permeabilize biological tissue. This electroporation process induces conductivity changes in the tissue, which are indicative of the extent of electroporation. In this study, we characterized the electroporation-induced conductivity changes using all treatment pulses instead of solely the first pulse as in conventional conductivity models. Rabbit liver tissue was employed to study the tissue conductivity changes caused by multiple, 100 μs pulses delivered through flat plate electrodes. Voltage and current data were recorded during treatment and used to calculate the tissue conductivity during the entire pulsing process. Temperature data were also recorded to quantify the contribution of Joule heating to the con

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC7248411 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature