CD24-targeted fluorescence imaging in patient-derived xenograft models of high-grade serous ovarian carcinoma.

ABSTRACT:

Background

The survival rate of patients with advanced high-grade serous ovarian carcinoma (HGSOC) remains disappointing. Clinically translatable orthotopic cell line xenograft models and patient-derived xenografts (PDXs) may aid the implementation of more personalised treatment approaches. Although orthotopic PDX reflecting heterogeneous molecular subtypes are considered the most relevant preclinical models, their use in therapeutic development is limited by lack of appropriate imaging modalities.

Methods

We developed novel orthotopic xenograft and PDX models for HGSOC, and applied a near-infrared fluorescently labelled monoclonal antibody targeting the cell surface antigen CD24 for non-invasive molecular imaging of epithelial ovarian cancer. CD24-Alexa Fluor 680 fluorescen

SUBMITTER: Kleinmanns K 

PROVIDER: S-EPMC7248428 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature