Active wrinkles to drive self-cleaning: A strategy for anti-thrombotic surfaces for vascular grafts.

ABSTRACT: The inner surfaces of arteries and veins are naturally anti-thrombogenic, whereas synthetic materials placed in blood contact commonly experience thrombotic deposition that can lead to device failure or clinical complications. Presented here is a bioinspired strategy for self-cleaning anti-thrombotic surfaces using actuating surface topography. As a first test, wrinkled polydimethylsiloxane planar surfaces are constructed that can repeatedly transition between smooth and wrinkled states. When placed in contact with blood, these surfaces display markedly less platelet deposition than control samples. Second, for the specific application of prosthetic vascular grafts, the potential of using pulse pressure, i.e. the continual variation of blood pressure between systole and diastole, to drive

SUBMITTER: Pocivavsek L 

PROVIDER: S-EPMC7248685 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature