Correlations Between the Genetic Variations in the COL1A1, COL5A1, COL12A1, and β-fibrinogen Genes and Anterior Cruciate Ligament Injury in Chinese Patients^a.

ABSTRACT:

Context

A variety of factors have been linked to the occurrence of anterior cruciate ligament injury (ACLI), including sex, familial factors, and genetic variations.

Objective

To find the genetic loci associated with ACLI and explore the genetic mechanism of ACLI in order to provide a genetic basis for the diagnosis, prognosis, and treatment of patients with ACLI.

Design

Cross-sectional study.

Setting

Hospital.

Patients or other participants

Data from 101 Chinese Yunnan Han patients with ACLI and 110 Yunnan Han individuals without ACLI (control group) were collected.

Main outcome measure(s)

The single nucleotide polymorphisms of COL1A1 rs1800012, COL5A1 rs12722 and rs13946, COL12A1 rs970547 and rs240736 and the rs1800787, rs18

SUBMITTER: Zhao D 

PROVIDER: S-EPMC7249278 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature