Lifestyle and the presence of helminths is associated with gut microbiome composition in Cameroonians.

ABSTRACT:

Background

African populations provide a unique opportunity to interrogate host-microbe co-evolution and its impact on adaptive phenotypes due to their genomic, phenotypic, and cultural diversity. We integrate gut microbiome 16S rRNA amplicon and shotgun metagenomic sequence data with quantification of pathogen burden and measures of immune parameters for 575 ethnically diverse Africans from Cameroon. Subjects followed pastoralist, agropastoralist, and hunter-gatherer lifestyles and were compared to an urban US population from Philadelphia.

Results

We observe significant differences in gut microbiome composition across populations that correlate with subsistence strategy and country. After these, the variable most strongly associated with gut microbiome structure in Cameroon

SUBMITTER: Rubel MA 

PROVIDER: S-EPMC7249393 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature