Electrostatically gated nanofluidic membrane for ultra-low power controlled drug delivery.

ABSTRACT: Patient-centered therapeutic management for chronic medical conditions is a desired but unmet need, largely attributable to the lack of adequate technologies for tailored drug administration. While triggered devices that control the delivery of therapeutics exist, they often rely on impractical continuous external activation. As such, next generation continuously tunable drug delivery systems independent of sustained external activation remain an elusive goal. Here we present the development and demonstration of a silicon carbide (SiC)-coated nanofluidic membrane that achieves reproducible and tunable control of drug release via electrostatic gating. By applying a low-intensity voltage to a buried electrode, we showed repeatable and reproducible in vitro release modulation of three model a

SUBMITTER: Di Trani N 

PROVIDER: S-EPMC7249613 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature