Quantitative susceptibility mapping detects neovascularization of the epiphyseal cartilage after ischemic injury in a piglet model of legg-calve-perthes disease.

ABSTRACT: BACKGROUND:Legg-Calvé-Perthes disease (LCPD) is a childhood hip disorder thought to be caused by disruption of blood supply to the developing femoral head. There is potential for imaging to help assess revascularization of the femoral head. PURPOSE:To investigate whether quantitative susceptibility mapping (QSM) can detect neovascularization in the epiphyseal cartilage following ischemic injury to the developing femoral head. STUDY TYPE:Prospective. ANIMAL MODEL:Right femoral head ischemia was surgically induced in 6-week-old male piglets. The animals were sacrificed 48 hours (n = 3) or 4 weeks (n = 7) following surgery, and the operated and contralateral control femoral heads were harvested for ex vivo MRI. FIELD STRENGTH/SEQUENCE:Preclinical 9.4T MRI to acquire susceptibility-weighted 3D

SUBMITTER: Johnson CP 

PROVIDER: S-EPMC7249674 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature