Interleukin-12 elicits a non-canonical response in B16 melanoma cells to enhance survival.
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ABSTRACT:
SUBMITTER: Byrne-Hoffman CN
PROVIDER: S-EPMC7249691 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
Interleukin-12 elicits a non-canonical response in B16 melanoma cells to enhance survival.
Byrne-Hoffman Christina N CN Deng Wentao W McGrath Owen O Wang Peng P Rojanasakul Yon Y Klinke David J DJ
Cell communication and signaling : CCS 20200525 1
<h4>Background</h4>Oncogenesis rewires signaling networks to confer a fitness advantage to malignant cells. For instance, the B16F0 melanoma cell model creates a cytokine sink for Interleukin-12 (IL-12) to deprive neighboring cells of this important anti-tumor immune signal. While a cytokine sink provides an indirect fitness advantage, does IL-12 provide an intrinsic advantage to B16F0 cells?<h4>Methods</h4>Acute in vitro viability assays were used to compare the cytotoxic effect of imatinib on ...[more]
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