Mapping of Ion and Substrate Binding Sites in Human Sodium Iodide Symporter (hNIS).

ABSTRACT: The human sodium iodide symporter (hNIS) is a theranostic reporter gene which concentrates several clinically approved SPECT and PET radiotracers and plays an essential role for the synthesis of thyroid hormones as an iodide transporter in the thyroid gland. Development of hNIS mutants which could enhance translocation of the desired imaging ions is currently underway. Unfortunately, it is hindered by lack of understanding of the 3D organization of hNIS and its relation to anion transport. There are no known crystal structures of hNIS in any of its conformational states. Homology modeling can be very effective in such situations; however, the low sequence identity between hNIS and relevant secondary transporters with available experimental structures makes the choice of a template and the

SUBMITTER: Zhekova HR 

PROVIDER: S-EPMC7249729 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature