In silico analysis of the molecular regulatory networks in peripheral arterial occlusive disease.

ABSTRACT:

Background

Peripheral arterial occlusive disease (PAOD) is a global public health concern that decreases the quality of life of the patients and can lead to disabilities and death. The aim of this study was to identify the genes and pathways associated with PAOD pathogenesis, and the potential therapeutic targets.

Methods

Differentially expressed genes (DEGs) and miRNAs related to PAOD were extracted from the GSE57691 dataset and through text mining. Additionally, bioinformatics analysis was applied to explore gene ontology, pathways and protein-protein interaction of those DEGs. The potential miRNAs targeting the DEGs and the transcription factors (TFs) regulating miRNAs were predicted by multiple different databases.

Results

A total of 59 DEGs were identified, which

SUBMITTER: Guan X 

PROVIDER: S-EPMC7250035 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature