Comparison of the pharmacological profiles of arginine vasopressin and oxytocin analogs at marmoset, macaque, and human vasopressin 1a receptor.

ABSTRACT: Arginine vasopressin (AVP) and oxytocin (OT) are nonapeptides that bind to G-protein coupled receptors and influence social behaviors. Consensus mammalian AVP and OT (Leu⁸-OT) sequences are highly conserved. In marmosets, an amino acid change in the 8th position of the peptide (Pro⁸-OT) exhibits unique structural and functional properties. There is ∼85 % structural homology between the OT receptor (OTR) and vasopressin 1a receptor (V1aR) resulting in significant cross-reactivity between the ligands and receptors. Chinese hamster ovary (CHO) cells expressing marmoset (mV1aR), macaque (qV1aR), or human vasopressin receptor 1a (hV1aR) were used to assess AVP, Leu⁸-OT and Pro⁸-OT pharmacological profiles. To assess activation of Gq, functional assays

SUBMITTER: Pierce ML 

PROVIDER: S-EPMC7250216 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature