Effects of Adiponectin on T2DM and Glucose Homeostasis: A Mendelian Randomization Study.

ABSTRACT:

Purpose

The associations of adiponectin with type 2 diabetes mellitus (T2DM), glucose homeostasis (including β-cell function index (HOMA-β), insulin resistance (HOMA-IR), fasting insulin (FI) and fasting glucose (FG)) have reported in epidemiological studies. However, the previous observational studies are prone to biases, such as reverse causation and residual confounding factors. Herein, a Mendelian Randomization (MR) study was conducted to determine whether causal effects exist among them.

Materials and and methods

Two-sample MR analyses and multiple sensitivity analyses were performed using the summary data from the ADIPOGen consortium, MAGIC Consortium, and a meta-analysis of GWAS with a considerable sample of T2DM (62,892 cases and 596,424 controls of European ancestry

SUBMITTER: Chen Z 

PROVIDER: S-EPMC7250315 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature