Long-Term Follow-Up of Advanced Liver Disease after Sustained Virological Response to Treatment of Hepatitis C with Direct-Acting Antivirals: Outcomes from a Real-World Portuguese Cohort.

ABSTRACT:

Background

Direct-acting antivirals (DAA) have revolutionized hepatitis C treatment, with high sustained virological response (SVR) rates reported, even in historically difficult-to-treat groups. SVR is associated with a decreased risk of hepatocellular carcinoma (HCC), need for transplantation, and overall and liver-related mortality. Data from real-life cohorts on the medium- to long-term outcomes of patients with advanced liver disease and DAA-induced SVR are still missing.

Objectives

To report and analyze the long-term outcomes of DAA-induced SVR in a real-life cohort of patients with advanced liver disease.

Method

In this retrospective, longitudinal, single-center study, we collected data from patients with chronic hepatitis C infection and advanced liver disease

SUBMITTER: Pereira Guedes T 

PROVIDER: S-EPMC7250343 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature