Individual housing of male C57BL/6J mice after weaning impairs growth and predisposes for obesity.

ABSTRACT: For (metabolic) research models using mice, singly housing is widely used for practical purposes to study e.g. energy balance regulation and derangements herein. Mouse (social) housing practices could however influence study results by modulating (metabolic) health outcomes. To study the effects of the social housing condition, we assessed parameters for energy balance regulation and proneness to (diet induced) obesity in male C57Bl/6J mice that were housed individually or socially (in pairs) directly after weaning, both at standard ambient temperature of 21°C. During adolescence, individually housed mice had reduced growth rate, while energy intake and energy expenditure were increased compared to socially housed counterparts. At 6 weeks of age, these mice had reduced lean body mass, but

SUBMITTER: Schipper L 

PROVIDER: S-EPMC7250426 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature