Comparative and Evolutionary Genomics of Isolates Provide Insight into the Pathoadaptation of Aeromonas.

ABSTRACT: Aeromonads are ubiquitous aquatic bacteria that cause opportunistic infections in humans, but their pathogenesis remains poorly understood. A pathogenomic approach was undertaken to provide insights into the emergence and evolution of pathogenic traits in aeromonads. The genomes of 64 Aeromonas strains representative of the whole genus were analyzed to study the distribution, phylogeny, and synteny of the flanking sequences of 13 virulence-associated genes. The reconstructed evolutionary histories varied markedly depending on the gene analyzed and ranged from vertical evolution, which followed the core genome evolution (alt and colAh), to complex evolution, involving gene loss by insertion sequence-driven gene disruption, horizontal gene transfer, and paraphyly with some virulence genes as

SUBMITTER: Talagrand-Reboul E 

PROVIDER: S-EPMC7250499 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature