Impact of Panel Gene Testing for Hereditary Breast and Ovarian Cancer on Patients.

ABSTRACT: Recent advances in next generation sequencing have enabled panel gene testing, or simultaneous testing for mutations in multiple genes for a clinical condition. With more extensive and widespread genetic testing, there will be increased detection of genes with moderate penetrance without established clinical guidelines and of variants of uncertain significance (VUS), or genetic variants unknown to either be disease-causing or benign. This study surveyed 232 patients who underwent genetic counseling for hereditary breast and ovarian cancer to examine the impact of panel gene testing on psychological outcomes, patient understanding, and utilization of genetic information. The survey used standardized instruments including the Impact of Event Scale (IES), Multidimensional Impact of Cancer Ris

SUBMITTER: Lumish HS 

PROVIDER: S-EPMC7250529 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature