Polyplex transfection from intracerebroventricular delivery is not significantly affected by traumatic brain injury.

ABSTRACT: Traumatic brain injury (TBI) is largely non-preventable and often kills or permanently disables its victims. Because current treatments for TBI merely ameliorate secondary effects of the initial injury like swelling and hemorrhaging, strategies for the induction of neuronal regeneration are desperately needed. Recent discoveries regarding the TBI-responsive migratory behavior and differentiation potential of neural progenitor cells (NPCs) found in the subventricular zone (SVZ) have prompted strategies targeting gene therapies to these cells to enhance neurogenesis after TBI. We have previously shown that plasmid polyplexes can non-virally transfect SVZ NPCs when directly injected in the lateral ventricles of uninjured mice. We describe the first reported intracerebroventricular transfectio

SUBMITTER: Peeler DJ 

PROVIDER: S-EPMC7250725 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature