SPECT Imaging of Muscle Injury with [^99mTc]MDP in a Mouse Model of Muscular Dystrophy.

ABSTRACT:

Purpose

Tc-99m methylene diphosphonate ([^99mTc]MDP) is an in vivo bone imaging agent that also accumulates in injured skeletal muscle cells. The objective of this study was to investigate if [^99mTc]MDP could be used to detect muscle injury in the mdx mouse model of Duchenne muscular dystrophy (DMD).

Procedures

Static whole-body single-photon emission computed tomography/computed tomography (CT) scans were acquired at 2 h post-injection of [^99mTc]MDP in two cohorts of animals at different sites: one cohort of mice at 6, 15, and 19 weeks of age, and a separate cohort at 16 weeks. The second cohort was also imaged with high-resolution CT at 8 weeks.

Results

mdx mice had higher [^99mTc]MDP uptake and significantly higher [⁹⁹

SUBMITTER: Gaut C 

PROVIDER: S-EPMC7250810 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature