Regulation of the small GTPase Ran by miR-802 modulates proliferation and metastasis in colorectal cancer cells.

ABSTRACT:

Background

The small GTPase Ran is upregulated in multiple cancers and fundamental for cancer cell survival and progression, but its significance and molecular mechanisms in colorectal cancer (CRC) remain elusive.

Methods

Ran expression was detected in CRC cell lines and tumour tissues. In vitro and in vivo functional assays were performed to examine the effects of Ran on cell proliferation and metastasis. The pathways and effectors regulated by Ran were explored by an unbiased screening. Bioinformatics prediction and experimental validation were used to identify the miRNA regulator for Ran.

Results

Ran expression was frequently increased in metastatic CRC cells and tissues, especially in metastatic tissues. The upregulation of Ran correlated with poor CRC patient pro

SUBMITTER: Wang X 

PROVIDER: S-EPMC7250854 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature