P2Y₁₄ receptor has a critical role in acute gouty arthritis by regulating pyroptosis of macrophages.

ABSTRACT: Nod-like receptor protein 3 (NLRP3)-mediated pyroptosis has a causal role in the pathogenesis of gout. P2Y₁₄ receptor (P2Y₁₄R) distributed in immune cells including macrophages is a Gi-coupled receptor that inhibits the synthesis of cAMP, which has been regarded as a potential regulator of inflammatory response. Nevertheless, the role of P2Y₁₄R in MSU-induced pyroptosis of macrophages involved in acute gouty arthritis is still unclear. In our present study, P2Y₁₄R knockout (P2Y₁₄R-KO) disrupted MSU-induced histopathologic changes in rat synoviums, accompanied with a significant inhibition of pyroptotic cell death characterized by Caspase-1/PI double-positive and blockade of NLRP3 inflammasome activation in synovial tissues, which was c

SUBMITTER: Li H 

PROVIDER: S-EPMC7250907 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature