Diagnostic value of ¹⁸F-FDG-PET to predict the tumour immune status defined by tumoural PD-L1 and CD8⁺tumour-infiltrating lymphocytes in oral squamous cell carcinoma.

ABSTRACT:

Background

Lately, immune checkpoint proteins, such as programmed death 1 (PD-1) and its ligand-1 (PD-L1), have garnered attention as a new target in oral squamous cell carcinoma (OSCC). Reportedly, fluoro-D-glucose (FDG)-uptake alteration by anti-PD-1 antibody treatment depicts the response in patients with lung cancer. This study aims to elucidate the correlations between tumour immune status, clinicopathological factors, ¹⁸F-FDG-uptake and cold tumour phenotypes as low PD-L1 expression/low CD8⁺tumour-infiltrating lymphocytes (TILs) in OSCC.

Methods

We performed immunohistochemical analysis of PD-L1, hypoxia-inducible factor 1 A (HIF-1A), glucose transporter type 1 (GLUT1), CD8, E-cadherin and Ki-67 on 59 operable OSCC samples. We assessed the correla

SUBMITTER: Togo M 

PROVIDER: S-EPMC7250916 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature