Tracing the Origins of the Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP).

ABSTRACT: Pituitary adenylate cyclase activating polypeptide (PACAP) is a well-conserved neuropeptide characteristic of vertebrates. This pluripotent hypothalamic neuropeptide regulates neurotransmitter release, intestinal motility, metabolism, cell division/differentiation, and immunity. In vertebrates, PACAP has a specific receptor (PAC₁) but it can also activate the Vasoactive Intestinal Peptide receptors (VPAC₁ and VPAC₂). The evolution of the vertebrate PACAP ligand - receptor pair has been well-described. In contrast, the situation in invertebrates is much less clear. The PACAP ligand - receptor pair in invertebrates has mainly been studied using heterologous antibodies raised against mammalian peptides. A few partial PACAP cDNA clones sharing >87% aa identity

SUBMITTER: Cardoso JCR 

PROVIDER: S-EPMC7251081 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature