Characteristics of the Urinary Microbiome From Patients With Gout: A Prospective Study.

ABSTRACT: The role of host microbes in the pathogenesis of several diseases has been established, and altered microbiomes have been related to diseases. However, the variability of the urinary microbiome in individuals with gout has not been evaluated to date. Therefore, we conducted the present prospective study to characterize the urinary microbiome and its potential relation to gout. Urine samples from 30 patients with gout and 30 healthy controls were analyzed by Illumina MiSeq sequencing of the 16S rRNA hypervariable regions, and the microbiomes were compared according to alpha-diversity indices, complexity (beta diversity) with principal component analysis, and composition with linear discriminant analysis effect size. The most significantly different taxa at the phylum and genus levels were i

SUBMITTER: Ning Y 

PROVIDER: S-EPMC7251145 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature