NADPH oxidases: Pathophysiology and therapeutic potential in age-associated pulmonary fibrosis.

ABSTRACT: Oxidative stress has been associated with a number of human fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). Although oxidative stress is associated with both fibrosis and aging, the precise cellular sources(s) of reactive oxygen species (ROS) that contribute to the disease pathogenesis remain poorly understood. NADPH oxidase (Nox) enzymes are an evolutionarily conserved family, where their only known function is the production of ROS. A growing body of evidence supports a link between excessive Nox-derived ROS and numerous chronic diseases (including fibrotic disease), which is most prevalent among the elderly population. In this review, we examine the evidence for Nox isoforms in the pathogenesis of IPF, and the potential to target this enzyme family for the treatment of

SUBMITTER: Kato K 

PROVIDER: S-EPMC7251244 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature