Social stress is lethal in the mdx model of Duchenne muscular dystrophy.

ABSTRACT:

Background

Duchenne muscular dystrophy (DMD) is caused by the loss of dystrophin. Severe and ultimately lethal, DMD progresses relatively slowly in that patients become wheelchair bound only around age twelve with a survival expectancy reaching the third decade of life.

Methods

The mildly-affected mdx mouse model of DMD, and transgenic DysΔMTB-mdx and Fiona-mdx mice expressing dystrophin or utrophin, respectively, were exposed to either mild (scruffing) or severe (subordination stress) stress paradigms and profiled for their behavioral and physiological responses. A subgroup of mdx mice exposed to subordination stress were pretreated with the beta-blocker metoprolol.

Findings

Subordination stress caused lethality in ∼30% of mdx mice within 24 h and ∼70% lethality with

SUBMITTER: Razzoli M 

PROVIDER: S-EPMC7251247 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature