Identification of the Hub Genes Related to Nerve Injury-Induced Neuropathic Pain.

ABSTRACT:

Background

The reactivity enhancement of pain sensitive neurons in the nervous system is a feature of the pathogenesis for neuropathic pain (NP), yet the underlying mechanisms need to be fully understood. In this study, we made an attempt to clarify the NP-related hub genes and signaling pathways so as to provide effective diagnostic and therapeutic methods toward NP.

Methods

Microarray expression profile GSE30691 including the mRNA-seq data of the spared nerve injury (SNI)-induced NP rats was accessed from the GEO database. Then, genes associated with NP development were screened using differential analysis along with random walk with restart (RWR). GO annotation and KEGG pathway analyses were performed to explore the biological functions and signaling pathways where the ge

SUBMITTER: Wang K 

PROVIDER: S-EPMC7251260 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature