Sinapine, but not sinapic acid, counteracts mitochondrial oxidative stress in cardiomyocytes.

ABSTRACT:

Introduction

When confronted to stress or pathological conditions, the mitochondria overproduce reactive species that participate in the cellular dysfunction. These organelles are however difficult to target with antioxidants. A feature of mitochondria that can be used for this is the negatively charged compartments they form. Most of mitochondrion-targeting antioxidants are therefore cationic synthetic molecules. Our hypothesis is that such mitochondriotropic traits might also exists in natural molecules.

Aim

We tested here whether sinapine, a natural phenolic antioxidant-bearing a permanent positive charge, can target mitochondria to modulate mitochondrial oxidative stress.

Methods

Experiments were performed in-vitro, in-cellulo, ex-vivo, and in-vivo, using cardiac

SUBMITTER: Boulghobra D 

PROVIDER: S-EPMC7251366 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature