Effect of Doxycycline on Aneurysm Growth Among Patients With Small Infrarenal Abdominal Aortic Aneurysms: A Randomized Clinical Trial.

ABSTRACT:

Importance

Abdominal aortic aneurysms affect more than 3% of US older adults.

Objective

To test whether doxycycline reduces the growth of abdominal aortic aneurysm over 2 years as measured by maximum transverse diameter.

Design, setting, and participants

Parallel, 2-group, randomized clinical trial that was conducted at 22 US clinical centers between May 2013 and January 2017, and enrolled patients 50 years or older with small (3.5-5.0 cm for men, 3.5-4.5 cm for women) infrarenal aneurysms. The final date of follow-up was July 31, 2018.

Interventions

Patients were randomized to receive twice daily for 2 years doxycycline 100 mg orally (as capsules) (n = 133) or placebo (n = 128).

Main outcomes and measures

The primary outcome was change in abdominal aort

SUBMITTER: Baxter BT 

PROVIDER: S-EPMC7251450 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature